Home / Dr. Silvia Ghirotto

 

Ghirotto_photoDr. Silvia Ghirotto is Assistant Professor at the University of Ferrara, Italy. Her main research interests are understanding the demographic processes underlying human expansion out of Africa and the genealogical relationships between human populations along their evolutionary history. In order to reconstruct the human past, Dr. Ghirotto employs population genetic approaches, including Approximate Bayesian Computation methods and other model-based techniques, for both contemporary and ancient samples. During her time at the Center, she will study worldwide human genomic data in order to shed light on migration patterns and mechanisms of adaptation that modern populations experienced after their expansion out of Africa.

Positions
2015 - presentAssistant Professor (RTD-b, tenure track) in Genetics (SSD BIO/18) at the University of Ferrara.
2013 - 2015Assistant Professor (RTD-b, tenure track) in Genetics (SSD BIO/18) at the University of Ferrara.
2011 - 2013Research fellowship at the Department of Life Sciences and Biotechnologies, University of Ferrara, Genetic data analysis and simulation of demographic processes.
2009 - 2011Research fellowship at the Department of Biology and Evolution, University of Ferrara, Biostatistical Analysis of Clinical Data.
Additional research experience
2015External Scientific Member of the Humanities Center for Advanced Studies, Tübingen, Germany. Principal Investigators: Professor Gerhard Jäger, Professor Katerina Harvati.
2014Visiting fellow at the University of Leicester (UK). Supervisor: Professor Mark Jobling
2010Research fellowship at the Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany. (for the DAAD, the German Academic Exchange Service, program). Supervisor: Dr Dr Brigitte Pakendorf
Teaching
2015 - 2016 Molecular Evolution (6 credits/48 hours). Master Degree in Biomolecular Sciences and Evolution, University of Ferrara.
2014 - 2015Molecular Evolution (6 credits/48 hours). Master Degree in Biomolecular Sciences and Evolution, University of Ferrara.
2013 - 2014Bioinformatic and Genome Analysis (6 credits/48 hours). Master Degree in Biomolecular and Cellular Sciences, University of Ferrara.
2012 - 2013Teaching Assistant of Genetics (Prof Guido Barbujani). University of Ferrara
2012 - 2013Teaching Assistant of Population Genetics (Prof Guido Barbujani). University of Ferrara
2011 - 2012Teaching Assistant of Genetics (Prof Guido Barbujani). University of Ferrara
2011 - 2012Teaching Assistant of Population Genetics (Prof Guido Barbujani). University of Ferrara
2001 - 2012Tutor of Genetics. University of Ferrara
2011Teacher Assistant at the Summer School In Conservation Genetics Of Marine Organisms, Chioggia (Italy)
2010 - 2011Teaching Assistant of Population Genetics (Prof Guido Barbujani). University of Ferrara
2010 - 2011Tutor of Genetics. University of Ferrara
Publications
In preparation
Zuzana Faltyskova, Hannes Schroeder, Susana Morano, Alfredo Prieto, Yolanda Espinoza, Ermanno Rizzi, Elena Gigli, Oscar Ramirez, Elena Pilli, Alessandra Modi, Aurelio Maragnoni, Silvia Ghirotto, Alessandro Pietrelli, Guido Barbujani, Giorgio Manzi, David Caramelli, Carles Lalueza-Fox, Toomas Kivisild and Maru Mormina. Ancient mitochondrial DNA analysis reveals geographic isolation of people in Tierra del Fuego.
Michela Leonardi, Silvia Ghirotto, Christine Weber, Norbert Benecke, Mark G. Thomas, Joachim Burger. The demography of horse before and after domestication: a computer simulation approach.
Submitted
Alessandra Modi, Francesca Tassi, Roberta Rosa Susca, Stefania Vai, Carlo Lugliè, Guido Barbujani, David Caramelli and Silvia Ghirotto. Complete mitochondrial sequences from Mesolithic Sardinians reveal insight into the origin and evolution of the first colonizers of the island.
Wibhu Kutanan, Jatupol Kampuansai, Metawee Srikummool, Daoroong Kangwanpong, Silvia Ghirotto, Andrea Brunelli, Mark Stoneking. Complete mitochondrial genomes of Thai and Lao populations indicate an ancient origin of Austroasiatic groups and demic diffusion in the spread of Tai-Kadai languages.
Giuseppe Longobardi, Mark Bartlett, Andrea Ceolin, Cristina Guardiano, Monica- Alexandrina Irimia, Dimitar Kazakov, Dimitris Michelioudakis, Nina Radkevich, Stefania Sarno, Alessio Boattini, Andrea Brunelli, Silvia Ghirotto, Marco Sazzini, Roberta Rosa Susca, Francesca Tassi, Donata Luiselli, Guido Barbujani, Davide Pettener. Who likes to travel alone? Grammars and genes in the history of Old World migrations.
2016
Jatupol Kampuansai, Wibhu Kutanan, Francesca Tassi, Massupa Kaewgahya, Silvia Ghirotto and Daoroong Kangwanpong. 2016. Effect of migration patterns on maternal genetic structure: a case of Tai-Kadai migration from China to Thailand. Journal of Human Genetics. Doi: 10.1038/jhg.2016.112.
Irene Lobon, Serena Tucci, Marc de Manuel, Silvia Ghirotto, Andrea Benazzo, Javier Prado-Martinez, Belen Lorente-Galdos, Kiwoong Nam, Marc Dabad, Jessica Hernandez-Rodriguez, David Comas, Arcadi Navarro, Mikkel H. Schierup, Aida M. Andres, Guido Barbujani, Christina Hvilsom, Tomas Marques-Bonet. 2016. Demographic history of the genus Pan inferred from whole mitochondrial genome reconstructions. Genome Biology and Evolution. 8(6):2020-30.
Hugo Reyes-Centeno, Silvia Ghirotto, Katerina Harvati. 2016. Genomic validation of the differential preservation of population history in modern human cranial anatomy. American Journal of Physical Anthropology. doi: 10.1002/ajpa.23060.
Irene Dall’Ara, Silvia Ghirotto, Selene Ingusci, Giulia Bagarolo, Cristiano Bertolucci and Guido Barbujani. 2016. Demographic history and adaptation account for clock gene diversity in humans. Heredity. 117(3):165-72
Giuseppe Longobardi, Andrea Ceolin, Aaron Ecay, Silvia Ghirotto, Cristina Guardiano, Monica-Alexandrina Irimia, Dimitris Michelioudakis, Nina Radkevich, Davide Pettener, Donata Luiselli & Guido Barbujani. 2016. Formal linguistics as a cue to demographic history. J Anthropol Sci. 94:147-55
Silvia Ghirotto, Francesca Tassi, Guido Barbujani, Linda Pattini, Caroline Hayward, Peter Vollenweider, Murielle Bochud, Luca Rampoldi, and Olivier Devuyst. 2016. The Uromodulin Gene Locus Shows Evidence of Pathogen Adaptation through Human Evolution. J Am Soc Nephrol. pii: ASN.2015070830.
Cesare de Filippo, Felix M. Key, Silvia Ghirotto, Andrea Benazzo, Juan R. Meneu, Antje Weihmann, NISC Comparative Sequence Program, Genís Parra, Eric D. Green, Aida M. Andrés. 2016. Recent Selection Changes in Human Genes under Long-Term Balancing Selection. Mol Biol Evol. 33(6):1435-47.
2015
Francesca Tassi, Silvia Ghirotto, Massimo Mezzavilla, Sibelle Torres Vilaça, Lisa De Santi, and Guido Barbujani. 2015. Early human dispersal from Africa: genomic evidence for multiple waves of migration. Investig Genet. 6,13.
Fernanda SG Kehdy, Wagner CS Magalhães, Mateus H Gouveia, Andrea Horimoto, Bernardo LHorta, Marilia O Scliar, Giordano B Soares-Souza, Moara Machado, Thiago P Leal, Fernanda Rodrigues-Soares, RennanMoreira, Gilderlánio S Araújo, RoxanaZamudio, Hanaisa de Pla e Sant Anna, Hadassa Santos, NúbiaEsteban, Rosemeire L. Fiaccone,Camila A Figueiredo, ThiagoMagalhães da Silva, Gustavo Nunes de Oliveira Costa, Sandra Beleza, Douglas E Berg, Lilia Cabrera, GuilhermeDebortoli, Denise Duarte, Silvia Ghirotto, Robert H Gilman, Vanessa F Gonçalves, Andrea R Marrero, Yara CN Muniz, Hansi Weissensteiner, Meredith Yeager, Laura C Rodrigues, Maria Fernanda Lima-Costa, MauricioBarreto, Alexandre Pereira, Maíra R Rodrigues, Eduardo Tarazona-Santos and The Brazilian EPIGEN Project Consortium. 2015. Origin and dynamics of admixture in Brazilians and its effect on the pattern of deleterious mutations. ProcNatlAcadSci USA. 112, 8696-701.
Giuseppe Longobardi, Silvia Ghirotto, Cristina Guardiano, Andrea Ceolin, Francesca Tassi, Andrea Benazzo, and Guido Barbujani. 2015. Across language families: Genome diversity mirrors grammar within Europe. American Journal of Physical Anthropology. 157, 630-40.
Chiara Batini, Pille Hallast, Daniel Zadik, Pierpaolo Maisano Delser, Andrea Benazzo, Silvia Ghirotto, Eduardo Arroyo, Walter Bodmer, Gianpiero Cavalleri, Peter de Knijff, Berit Myhre Dupuy, Turi E. King, Adolfo López de Munain, Jelena Milasin, Andrea Novelletto, Horolma Pamjav, Antti Sajantila, Asli Tolun, Bruce Winney, Mark A. Jobling. 2015. Large-scale recent expansion of European patrilineages shown by population resequencing. Nature Communications. 19, 6:715.
Andrea Benazzo, Silvia Ghirotto, Sibelle Torres Vilaca and Sean M Hoban. 2015. Using ABC and microsatellite data to detect multiple introductions of invasive species from a single source. Heredity. 115, 262-72.
Suparat Srithawong, Metawee Srikummool, Pittayawat Pittayaporn, Silvia Ghirotto, Panuwan Chanthawannakul, Jie Sun, Arthur Eisenberg, Ranajit Chakraborty and Wibhu Kutanan. 2015. Genetic and Linguistic Correlation of Kra-Dai Speaking Groups in Thailand. Journal of Human Genetics. 60, 371-80.
Martina Lari, Fabio Di Vincenzo, Andrea Borsato, Silvia Ghirotto, Mario Micheli, Carlotta Balsamo, Carmine Collina, Gianluca De Bellis, Giacomo Giacobini, Elena Gigli, John C. Hellstrom, Antonella Lannino, Alessandra Modi, Alessandro Pietrelli, Elena Pilli, Antonio Profico, Oscar Ramirez, Ermanno Rizzi, Stefania Vai, Donata Venturo, Marcello Piperno, CarlesLalueza Fox, Guido Barbujani , David Caramelli & Giorgio Manzi. 2015. The Neanderthal in the karst: dating, paleogenetics and morphology of the skeleton from Altamura (Italy). Journal of Human Evolution. 82, 88-94.
Stefania Vai, Silvia Ghirotto, Elena Pilli, Francesca Tassi, Martina Lari, Ermanno Rizzi, CarlesLalueza-Fox, Laura Matas-Lalueza, Oscar Ramirez, Alessandro Achilli, Anna Olivieri, Antonio Torroni, Caterina Giostra, Elena Bedini, Luisella Pejrani Baricco, Alberto Piazza, KrishnaVeeramah, Patrick Geary, David Caramelli, and Guido Barbujani. 2015. Genealogical relationships between early medieval and modern inhabitants of Piedmont. PLoS ONE10(1):e0116801.
Massimo Mezzavilla and Silvia Ghirotto. 2015. NeON: an R package to estimate human effective population size and divergence time from patterns of linkage disequilibrium between SNPs. J Comput Sci Syst Biol. 8, 037-044.
2014
Marilia O Scliar, Mateus H Gouveia, Andrea Benazzo, Silvia Ghirotto, Nelson J Fagundes, Thiago P Leal, Wagner CS Magalhães, Latife Pereira, Maira R Rodrigues, Giordano Soares-Souza, Lilia Cabrera, Douglas Berg, Robert H Gilman, Giorgio Bertorelle, Eduardo Tarazona-Santos. 2014. Amazon Yunga Natives split from Andeans less than 5000 YBP: implications for South American prehistory. BMC Evolutionary Biology. 14, 174.
Wibhu Kutanan, Silvia Ghirotto, Giorgio Bertorelle, SuparatSrithawong, KanokpornSrithongdaeng, NattaponPonlatham, and DaoroongKangwanpong. 2014. Geography has more influence than language on maternal genetic structure of various Northeastern Thai ethnicities. Journal of Human Genetics. 59, 512-520.
PNAS.coverHugo Reyes-Centeno, Silvia Ghirotto, Florent Détroit, Dominique Grimaud- Hervé, Guido Barbujani, and Katerina Harvati. 2014. Genomic and Cranial Phenotype Data Support Multiple Modern Human Dispersals from Africa and a Southern Route into Asia. ProcNatlAcadSci USA. 111, 7248-53.
2013
Guido Barbujani, Silvia Ghirotto, Francesca Tassi. 2013. Nine things to remember about human genome diversity. Tissue Antigens. 82, 155-164.
Francesca Tassi, Silvia Ghirotto, David Caramelli and Guido Barbujani. 2013. Genetic Evidence Does Not Support An Etruscan Origin In Anatolia. American Journal of Physical Anthropology. 152, 11-18
Silvia Ghirotto, Francesca Tassi, Erica Fumagalli, Vincenza Colonna, Anna Sandionigi, Martina Lari, Stefania Vai, Emmanuele Petiti, Giorgio Corti, Ermanno Rizzi, Gianluca De Bellis, David Caramelli and Guido Barbujani. 2013. Origins and evolution of the Etruscans’ DNA. PLoS One. 8(2):e55519
2011
Silvia Ghirotto, Luca Penso-Dolfin and Guido Barbujani. 2011. Genomic evidence for an African expansion of anatomically-modern humans by a Southern route. Human Biology. 83, 77-489.
Silvia Ghirotto, Francesca Tassi, Andrea Benazzo, Guido Barbujani. 2011. No evidence of Neandertal admixture in Cro-Magnoid and modern European mitochondrial genomes. American Journal of Physical Anthropology. 146, 242- 52
2010
Guido Barbujani and Silvia Ghirotto. 2010. Origin of the Tuscans. Standard Article in: "ENCYCLOPEDIA OF LIFE SCIENCES".
Silvia Ghirotto, Stefano Mona, Andrea Benazzo, Francesco Paparazzo, David Caramelli, Guido Barbujani. 2010. Inferring Genealogical Processes from Patterns of Bronze-Age and Modern DNA variation in Sardinia. MolecularBiology and Evolution. 27, 875-86.
2009
Silvia Guimaraes, Silvia Ghirotto, Andrea Benazzo, Lucio Milani, Martina Lari, Elena Pilli, Elena Pecchioli, Francesco Mallegni, Barbara Lippi, Francesca Bertoldi, Sauro Gelichi, Antonella Casoli, Elise M. S. Belle, David Caramelli, Guido Barbujani. 2009 Genealogical discontinuities among Etruscan, Medieval and contemporary Tuscans.Molecular Biology and Evolution.26, 2157-66
Elise M. S. Belle, Andrea Benazzo, Silvia Ghirotto, Vincenza Colonna, Guido Barbujani. 2009. Comparing models on the genealogical relationships among Neandertal, Cro-Magnoid and modern Europeans by serial coalescent simulations. Heredity.102, 218-25.
 

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